278331

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 653947..654524 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name brnT Uniprot ID Q92S20
Locus tag QC756_RS03050 Protein ID WP_010968707.1
Coordinates 653947..654210 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q92KN5
Locus tag QC756_RS03055 Protein ID WP_010968708.1
Coordinates 654207..654524 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS03010 (QC756_03010) 649276..649716 + 441 WP_010968702.1 DUF2948 family protein -
QC756_RS03015 (QC756_03015) 649781..651085 + 1305 WP_010968703.1 histidinol dehydrogenase -
QC756_RS03020 (QC756_03020) 651082..651558 + 477 WP_010968704.1 UPF0262 family protein -
QC756_RS03025 (QC756_03025) 651572..652051 + 480 WP_010968705.1 low molecular weight phosphatase family protein -
QC756_RS03030 (QC756_03030) 652209..652427 + 219 WP_004435948.1 translation initiation factor IF-1 -
QC756_RS03035 (QC756_03035) 652525..653145 + 621 WP_004435951.1 Maf-like protein -
QC756_RS03040 (QC756_03040) 653150..653362 + 213 WP_010968706.1 DNA gyrase inhibitor YacG -
QC756_RS03050 (QC756_03050) 653947..654210 + 264 WP_010968707.1 BrnT family toxin Toxin
QC756_RS03055 (QC756_03055) 654207..654524 + 318 WP_010968708.1 BrnA antitoxin family protein Antitoxin
QC756_RS03060 (QC756_03060) 654727..655191 - 465 WP_013844019.1 type II toxin-antitoxin system HicB family antitoxin -
QC756_RS03065 (QC756_03065) 655188..655376 - 189 WP_013844020.1 hypothetical protein -
QC756_RS03070 (QC756_03070) 655696..656796 + 1101 WP_010968710.1 hypothetical protein -
QC756_RS03075 (QC756_03075) 656783..657865 + 1083 WP_010968711.1 nucleotidyltransferase family protein -
QC756_RS03080 (QC756_03080) 658068..658379 + 312 WP_004435964.1 hypothetical protein -
QC756_RS03085 (QC756_03085) 658659..659048 - 390 WP_013844021.1 DUF930 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(26-103)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9821.16 Da        Isoelectric Point: 10.3413

>T278331 WP_010968707.1 NZ_CP123003:653947-654210 [Sinorhizobium meliloti]
MRIVWGEPKRRANLEKHGFDFADVSDLDWASALIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP

Download         Length: 264 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12197.83 Da        Isoelectric Point: 10.0883

>AT278331 WP_010968708.1 NZ_CP123003:654207-654524 [Sinorhizobium meliloti]
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92S20

Antitoxin

Source ID Structure
AlphaFold DB Q92KN5

References