Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 183831..184390 Replicon plasmid unnamed2
Accession NZ_CP123002
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QEO92_RS32090 Protein ID WP_210058772.1
Coordinates 183831..184052 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QEO92_RS32095 Protein ID WP_210058774.1
Coordinates 184049..184390 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS32065 (QEO92_32065) 179089..179799 - 711 WP_210058761.1 ParA family protein -
QEO92_RS32070 (QEO92_32070) 180261..180671 + 411 WP_280107563.1 plasmid mobilization relaxosome protein MobC -
QEO92_RS32075 (QEO92_32075) 180671..183067 + 2397 WP_210058765.1 conjugal transfer protein TraA -
QEO92_RS32080 (QEO92_32080) 183078..183266 + 189 WP_210058767.1 hypothetical protein -
QEO92_RS32085 (QEO92_32085) 183256..183540 - 285 WP_210058769.1 hypothetical protein -
QEO92_RS32090 (QEO92_32090) 183831..184052 + 222 WP_210058772.1 type II toxin-antitoxin system HicA family toxin Toxin
QEO92_RS32095 (QEO92_32095) 184049..184390 + 342 WP_210058774.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QEO92_RS32100 (QEO92_32100) 184493..186526 - 2034 WP_210058776.1 type IV secretory system conjugative DNA transfer family protein -
QEO92_RS32105 (QEO92_32105) 186523..187551 - 1029 WP_227705918.1 P-type DNA transfer ATPase VirB11 -
QEO92_RS32110 (QEO92_32110) 187511..188761 - 1251 WP_210058780.1 type IV secretion system protein VirB10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..379813 379813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(12-62)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8037.29 Da        Isoelectric Point: 8.0583

>T278329 WP_210058772.1 NZ_CP123002:183831-184052 [Neorhizobium petrolearium]
VFADPVLAGIVWRDIEALFVACGAEITEGQGSRVRVVLNGVRAVFHRPHPQKETDKGGVKSVRRFLLEAEIQP

Download         Length: 222 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12700.31 Da        Isoelectric Point: 4.9626

>AT278329 WP_210058774.1 NZ_CP123002:184049-184390 [Neorhizobium petrolearium]
MTTMHYKGYEAVVEFDEDADIFHGEVVNMRDVITFQGTSAAELKQAMADSIEDYLVFCKERGEEPEKPFSGQFVVRTEPS
IHKAVSSAARREGVSLNKWVTQALERAVSRKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References