Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2998513..2999183 Replicon chromosome
Accession NZ_CP123000
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name vapC Uniprot ID A0A095VGK5
Locus tag QEO92_RS14885 Protein ID WP_037149593.1
Coordinates 2998513..2998932 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0M3AZ99
Locus tag QEO92_RS14890 Protein ID WP_037149590.1
Coordinates 2998929..2999183 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS14860 (QEO92_14860) 2994636..2994947 - 312 WP_227703555.1 helix-turn-helix domain-containing protein -
QEO92_RS14865 (QEO92_14865) 2995202..2995928 + 727 Protein_2937 hypothetical protein -
QEO92_RS14870 (QEO92_14870) 2995973..2997484 - 1512 WP_227703556.1 hypothetical protein -
QEO92_RS14875 (QEO92_14875) 2997716..2998117 - 402 WP_227703557.1 tRNA(fMet)-specific endonuclease VapC -
QEO92_RS14880 (QEO92_14880) 2998117..2998347 - 231 WP_037149595.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QEO92_RS14885 (QEO92_14885) 2998513..2998932 - 420 WP_037149593.1 type II toxin-antitoxin system VapC family toxin Toxin
QEO92_RS14890 (QEO92_14890) 2998929..2999183 - 255 WP_037149590.1 plasmid stabilization protein Antitoxin
QEO92_RS14895 (QEO92_14895) 2999664..2999918 - 255 WP_227705173.1 type II toxin-antitoxin system VapC family toxin -
QEO92_RS14900 (QEO92_14900) 2999958..3000210 - 253 Protein_2944 IS110 family transposase -
QEO92_RS14905 (QEO92_14905) 3000416..3001945 - 1530 WP_227703558.1 ABC transporter substrate-binding protein -
QEO92_RS14910 (QEO92_14910) 3001973..3002800 - 828 WP_227703559.1 ABC transporter permease -
QEO92_RS14915 (QEO92_14915) 3002797..3003768 - 972 WP_227703560.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14945.21 Da        Isoelectric Point: 4.8231

>T278325 WP_037149593.1 NZ_CP123000:c2998932-2998513 [Neorhizobium petrolearium]
MILLDTNVISEPWKPVPDAAVIDWLDAQAIETLFLSAITIAELRFGIAAMPSGRRQTILRDRLEGEVLPHFSERILPFDL
ATSQFYSELMACARVSGKAIGTADGYIAASAAANGLAVATRDTSPFAAAGLKVINPWSR

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9285.49 Da        Isoelectric Point: 6.2285

>AT278325 WP_037149590.1 NZ_CP123000:c2999183-2998929 [Neorhizobium petrolearium]
MPAVTIRNLSDETHRALRLRAAHHGRSTEAEIRDIIEAAVRPPERVKLGSLLAAIGRDAELSDSDVEALQKSRDKTPAEP
MTFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095VGK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M3AZ99

References