Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2991759..2992333 Replicon chromosome
Accession NZ_CP123000
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name mazF Uniprot ID A0A095XL15
Locus tag QEO92_RS14840 Protein ID WP_037149607.1
Coordinates 2991759..2992112 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A095VFV3
Locus tag QEO92_RS14845 Protein ID WP_037149604.1
Coordinates 2992109..2992333 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS14820 (QEO92_14820) 2987375..2988715 + 1341 WP_227703553.1 ATP-binding protein -
QEO92_RS14825 (QEO92_14825) 2988832..2989371 + 540 WP_227703554.1 hypothetical protein -
QEO92_RS14830 (QEO92_14830) 2989541..2989783 + 243 WP_037155660.1 cysteine rich repeat-containing protein -
QEO92_RS14835 (QEO92_14835) 2990424..2991710 + 1287 Protein_2931 IS21 family transposase -
QEO92_RS14840 (QEO92_14840) 2991759..2992112 - 354 WP_037149607.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QEO92_RS14845 (QEO92_14845) 2992109..2992333 - 225 WP_037149604.1 antitoxin MazE family protein Antitoxin
QEO92_RS14850 (QEO92_14850) 2992654..2992869 - 216 WP_037149602.1 AlpA family phage regulatory protein -
QEO92_RS14855 (QEO92_14855) 2993390..2994643 - 1254 WP_037149788.1 HipA domain-containing protein -
QEO92_RS14860 (QEO92_14860) 2994636..2994947 - 312 WP_227703555.1 helix-turn-helix domain-containing protein -
QEO92_RS14865 (QEO92_14865) 2995202..2995928 + 727 Protein_2937 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2990436..2991737 1301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(11-74)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12833.72 Da        Isoelectric Point: 5.2033

>T278323 WP_037149607.1 NZ_CP123000:c2992112-2991759 [Neorhizobium petrolearium]
MRRGDIWTVAGGKDYAGKPRPVVIMQDDSFDGTDSITVCAFTSDDTEAPLFRLPVAPDERNGLRLSSRLMVDKITTVPKS
KIGEKVGRLDDEDIVRLNQAMLVFLGLAVSPRVRGEA

Download         Length: 354 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8091.17 Da        Isoelectric Point: 10.2982

>AT278323 WP_037149604.1 NZ_CP123000:c2992333-2992109 [Neorhizobium petrolearium]
MVSASKPKPTRVKVGEHRARLRAQGLRPIQIWVPDVRAPSFKVEAHRQSLAVAASAQAADDQAFIDAVSDWGDE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095XL15

Antitoxin

Source ID Structure
AlphaFold DB A0A095VFV3

References