278321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2615113..2615708 Replicon chromosome
Accession NZ_CP123000
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QEO92_RS13150 Protein ID WP_227703337.1
Coordinates 2615113..2615301 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QEO92_RS13155 Protein ID WP_227703338.1
Coordinates 2615304..2615708 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS13130 (QEO92_13130) 2610721..2612028 + 1308 WP_227703333.1 guanine deaminase -
QEO92_RS13135 (QEO92_13135) 2612064..2612969 + 906 WP_227703334.1 adenylate/guanylate cyclase domain-containing protein -
QEO92_RS13140 (QEO92_13140) 2613077..2614222 + 1146 WP_227703335.1 alpha-hydroxy acid oxidase -
QEO92_RS13145 (QEO92_13145) 2614232..2614999 - 768 WP_227703336.1 hypothetical protein -
QEO92_RS13150 (QEO92_13150) 2615113..2615301 + 189 WP_227703337.1 type II toxin-antitoxin system HicA family toxin Toxin
QEO92_RS13155 (QEO92_13155) 2615304..2615708 + 405 WP_227703338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QEO92_RS13160 (QEO92_13160) 2615714..2616463 - 750 WP_227703339.1 metallophosphoesterase family protein -
QEO92_RS13165 (QEO92_13165) 2616463..2616819 - 357 WP_227703340.1 hydroxyisourate hydrolase -
QEO92_RS13170 (QEO92_13170) 2616816..2617316 - 501 WP_227703341.1 ureidoglycolate lyase -
QEO92_RS13175 (QEO92_13175) 2617346..2617708 - 363 WP_227703342.1 DUF86 domain-containing protein -
QEO92_RS13180 (QEO92_13180) 2617705..2617995 - 291 WP_227703343.1 nucleotidyltransferase family protein -
QEO92_RS13185 (QEO92_13185) 2618069..2618431 - 363 WP_227703344.1 DUF86 domain-containing protein -
QEO92_RS13190 (QEO92_13190) 2618428..2618718 - 291 WP_227703345.1 nucleotidyltransferase family protein -
QEO92_RS13195 (QEO92_13195) 2618776..2619798 - 1023 WP_227703346.1 allantoicase -
QEO92_RS13200 (QEO92_13200) 2619799..2620296 - 498 WP_227703347.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7019.28 Da        Isoelectric Point: 11.3897

>T278321 WP_227703337.1 NZ_CP123000:2615113-2615301 [Neorhizobium petrolearium]
MRSAEVIALLRKDGWIELAQKGSHVQFKHPEKPGRVTVPHPKRDIPLGTLRSIEKQAGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14252.96 Da        Isoelectric Point: 4.3416

>AT278321 WP_227703338.1 NZ_CP123000:2615304-2615708 [Neorhizobium petrolearium]
MSNYIGLIRKEAGSDYGVSFPDFPGVVTAGSTLDEARQMAEEALAFHVEGMAEDGEAVPEPSSLEGVMSDPANRDGVAIL
VSLKTQAAKAVRINVTLPEDVLQRIDTFAEASGLSRSGFLARAARHEMERNTAV

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References