Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3516411..3516880 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name relE Uniprot ID A0A0W0N3W2
Locus tag PFLA506_RS15495 Protein ID WP_019816805.1
Coordinates 3516411..3516686 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0N3M6
Locus tag PFLA506_RS15500 Protein ID WP_014718861.1
Coordinates 3516686..3516880 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS15475 3511412..3512656 - 1245 WP_014718857.1 glutathione-dependent formaldehyde dehydrogenase -
PFLA506_RS15480 3512740..3513858 - 1119 WP_014718858.1 carboxylate-amine ligase -
PFLA506_RS15485 3513866..3514810 - 945 WP_014718859.1 class I SAM-dependent methyltransferase -
PFLA506_RS15490 3514822..3516201 - 1380 WP_014718860.1 iron-containing redox enzyme family protein -
PFLA506_RS15495 3516411..3516686 - 276 WP_019816805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFLA506_RS15500 3516686..3516880 - 195 WP_014718861.1 hypothetical protein Antitoxin
PFLA506_RS15505 3517026..3518768 - 1743 WP_003192009.1 ABC transporter substrate-binding protein -
PFLA506_RS15510 3518816..3519088 - 273 WP_014718862.1 DUF2160 domain-containing protein -
PFLA506_RS15515 3519100..3519900 - 801 WP_003192012.1 carbohydrate ABC transporter permease -
PFLA506_RS15520 3519911..3520777 - 867 WP_014718863.1 sugar ABC transporter permease -
PFLA506_RS15525 3520774..3521871 - 1098 WP_014718864.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10361.94 Da        Isoelectric Point: 5.5976

>T27832 WP_019816805.1 NC_017911:c3516686-3516411 [Pseudomonas fluorescens A506]
MLSVVWLDEAISDLIDIVTFIAEENPGAARRIKTRLEGAPLPLTEHPYLYPNGRVPGTREVVVHPNYVLVYRVTAERIEI
VNVLHARQEYP

Download         Length: 276 bp

>T27832 NC_017911:c3516686-3516411 [Pseudomonas fluorescens A506]
ATGTTAAGCGTTGTTTGGCTTGATGAGGCTATCAGCGACCTGATTGACATCGTTACTTTCATTGCAGAAGAGAATCCTGG
GGCGGCGCGACGTATCAAGACACGTCTTGAAGGTGCGCCTCTGCCACTGACCGAGCATCCTTACCTGTATCCGAACGGCC
GTGTGCCCGGTACGCGGGAGGTCGTCGTTCACCCCAATTACGTCCTAGTGTATCGAGTAACAGCAGAGCGCATCGAGATA
GTCAACGTGTTGCACGCTCGGCAAGAGTATCCCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7141.11 Da        Isoelectric Point: 4.7301

>AT27832 WP_014718861.1 NC_017911:c3516880-3516686 [Pseudomonas fluorescens A506]
MGVPLSPIVSEFETEEQANSHDLWFRAKVEKSLANPGPGVPHDEVMARVEAIILEAERKQWAKA

Download         Length: 195 bp

>AT27832 NC_017911:c3516880-3516686 [Pseudomonas fluorescens A506]
ATGGGTGTTCCACTTTCCCCAATTGTTTCCGAATTTGAAACCGAGGAGCAGGCGAATAGTCATGATCTTTGGTTTCGCGC
CAAAGTCGAAAAAAGCTTGGCCAACCCCGGACCCGGTGTACCCCATGACGAAGTCATGGCGAGGGTCGAGGCGATTATCC
TTGAAGCAGAACGCAAGCAGTGGGCCAAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N3W2

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N3M6

References