278318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1356704..1357271 Replicon chromosome
Accession NZ_CP123000
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name brnT Uniprot ID A0A095VDR5
Locus tag QEO92_RS06920 Protein ID WP_037150051.1
Coordinates 1357014..1357271 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A095XJ03
Locus tag QEO92_RS06915 Protein ID WP_037150054.1
Coordinates 1356704..1357024 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS06885 (QEO92_06885) 1351731..1352324 + 594 WP_037150061.1 LysE family translocator -
QEO92_RS06890 (QEO92_06890) 1352508..1353710 - 1203 WP_037150059.1 multidrug effflux MFS transporter -
QEO92_RS06895 (QEO92_06895) 1353880..1354536 + 657 WP_052182831.1 TetR/AcrR family transcriptional regulator -
QEO92_RS06900 (QEO92_06900) 1354541..1355314 - 774 WP_037150056.1 NAD kinase -
QEO92_RS06910 (QEO92_06910) 1355714..1356070 + 357 WP_200883942.1 hypothetical protein -
QEO92_RS06915 (QEO92_06915) 1356704..1357024 - 321 WP_037150054.1 BrnA antitoxin family protein Antitoxin
QEO92_RS06920 (QEO92_06920) 1357014..1357271 - 258 WP_037150051.1 BrnT family toxin Toxin
QEO92_RS06925 (QEO92_06925) 1358192..1358551 + 360 WP_052182821.1 hypothetical protein -
QEO92_RS06930 (QEO92_06930) 1359892..1360932 + 1041 WP_037150045.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-79)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-104)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9690.15 Da        Isoelectric Point: 5.6158

>T278318 WP_037150051.1 NZ_CP123000:c1357271-1357014 [Neorhizobium petrolearium]
MEITYDEHKRLTNIEKHFGLDFADLDMDFFEASTIIPSREDRLKAIGEFRGMIVIAVIFTPLGSEAISVISMRPASSKER
KVHGY

Download         Length: 258 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11996.71 Da        Isoelectric Point: 10.4704

>AT278318 WP_037150054.1 NZ_CP123000:c1357024-1356704 [Neorhizobium petrolearium]
MATKFSSKRPLTKEEEAEIQRMIASDPDAPEATNEELAKAKPFREALPHLAASIDRERARRGRPPIEKPRKHVSLRLDPD
IIDHYKATGKGWQSRMNEALRKAAGL

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095VDR5

Antitoxin

Source ID Structure
AlphaFold DB A0A095XJ03

References