Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5018116..5018774 Replicon chromosome
Accession NZ_CP122994
Organism Mycolicibacterium aubagnense strain HPB1.1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QDT91_RS24210 Protein ID WP_138228594.1
Coordinates 5018116..5018553 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag QDT91_RS24215 Protein ID WP_138228593.1
Coordinates 5018556..5018774 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDT91_RS24185 (QDT91_24180) 5013212..5013460 - 249 WP_138228598.1 hypothetical protein -
QDT91_RS24190 (QDT91_24185) 5013571..5014770 + 1200 WP_138228597.1 acetyl-CoA acetyltransferase -
QDT91_RS24195 (QDT91_24190) 5014767..5016263 + 1497 WP_138228596.1 carotenoid oxygenase family protein -
QDT91_RS24200 (QDT91_24195) 5016263..5017153 + 891 WP_179970220.1 winged helix-turn-helix transcriptional regulator -
QDT91_RS24205 (QDT91_24200) 5017205..5017975 - 771 WP_138228595.1 VOC family protein -
QDT91_RS24210 (QDT91_24205) 5018116..5018553 - 438 WP_138228594.1 SRPBCC family protein Toxin
QDT91_RS24215 (QDT91_24210) 5018556..5018774 - 219 WP_138228593.1 antitoxin Antitoxin
QDT91_RS24220 (QDT91_24215) 5018824..5021238 - 2415 WP_138228592.1 cation-translocating P-type ATPase -
QDT91_RS24225 (QDT91_24220) 5021315..5022424 - 1110 WP_138228591.1 MBL fold metallo-hydrolase -
QDT91_RS24230 (QDT91_24225) 5022424..5023158 - 735 WP_138228590.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15577.05 Da        Isoelectric Point: 9.5948

>T278310 WP_138228594.1 NZ_CP122994:c5018553-5018116 [Mycolicibacterium aubagnense]
MAKLASSIEVPLSPEKAWEAASDLSRYDDWLSIHRMWRSTLPETLGKGTQISSVVEVKGMLNRVDWTIVHYNPPGSLTLN
GVGKGGVRVKLMAKITPAEAGSNVAFDVHLGGPALFGPIGMVVAAALRSDIHHSLEKFKALFASV

Download         Length: 438 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7510.32 Da        Isoelectric Point: 4.2092

>AT278310 WP_138228593.1 NZ_CP122994:c5018774-5018556 [Mycolicibacterium aubagnense]
MGFLDKVKDLAAQNADKVEAAIEKVGDIVDEKTDGKFKSVVDSAQEAAKKAVAGEQPAEAPAPPAEGTQEQQ

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References