Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3479336..3479949 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name hicA Uniprot ID A0A0W0N4L4
Locus tag PFLA506_RS15305 Protein ID WP_014718823.1
Coordinates 3479336..3479587 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A854B833
Locus tag PFLA506_RS15310 Protein ID WP_014718824.1
Coordinates 3479584..3479949 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS15305 3479336..3479587 + 252 WP_014718823.1 type II toxin-antitoxin system HicA family toxin Toxin
PFLA506_RS15310 3479584..3479949 + 366 WP_014718824.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PFLA506_RS15315 3479950..3481122 - 1173 WP_014718825.1 MFS transporter -
PFLA506_RS15320 3481255..3481842 + 588 WP_014718826.1 TetR/AcrR family transcriptional regulator -
PFLA506_RS15325 3481826..3483181 - 1356 WP_014718827.1 MATE family efflux transporter -
PFLA506_RS15330 3483262..3484092 - 831 WP_014718828.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9526.11 Da        Isoelectric Point: 10.0459

>T27831 WP_014718823.1 NC_017911:3479336-3479587 [Pseudomonas fluorescens A506]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDMGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T27831 NC_017911:3479336-3479587 [Pseudomonas fluorescens A506]
GTGTCCAAGAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTTACCTGGTCTGAGCTCGTCACGTTATT
ACGCCGATTGGGATACACACAGATTGAAGGGGCCGGAAGCCGGGTCAAGTTCGACATGGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13248.12 Da        Isoelectric Point: 7.3725

>AT27831 WP_014718824.1 NC_017911:3479584-3479949 [Pseudomonas fluorescens A506]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Download         Length: 366 bp

>AT27831 NC_017911:3479584-3479949 [Pseudomonas fluorescens A506]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAGGACAACTGCCTGTTTGGTAAAAT
CCTGTTCATCAAGGCATTGGTGAGCTATGAAGGCAAAACTGTGGCTGAACTGGACGCAGCCTTCCGTGGCGCGGTGGATG
ATTATCTCGCTACCTGCCAGAGCCTGGGGCACACGCCGGAGAAACCGTGCAAAGGTTCATTCAACGTACGTGTCGGGCAT
GACTTGCATTTGGCCGCTGCCCTGGCGGCAAACCGTAAGAAAGTGACATTGAATGATCTCACGCGTCAGGCGCTGAACGA
ATTTCTGCAGCATCACTACCCAGAGCCATGCCCGACGATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N4L4

Antitoxin

Source ID Structure
AlphaFold DB A0A854B833

References