Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 3298..4651 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP122988 | ||
| Organism | Aeromonas salmonicida strain JNG | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A807ZF23 |
| Locus tag | QDU35_RS22900 | Protein ID | WP_042468256.1 |
| Coordinates | 3298..4263 (-) | Length | 322 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A807ZF76 |
| Locus tag | QDU35_RS22905 | Protein ID | WP_042468273.1 |
| Coordinates | 4253..4651 (-) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDU35_RS22870 (QDU35_22870) | 1..312 | + | 312 | WP_042468251.1 | helix-turn-helix transcriptional regulator | - |
| QDU35_RS22875 (QDU35_22875) | 344..1258 | + | 915 | WP_280101161.1 | reverse transcriptase family protein | - |
| QDU35_RS22880 (QDU35_22880) | 1364..1546 | - | 183 | WP_042468252.1 | hypothetical protein | - |
| QDU35_RS22885 (QDU35_22885) | 1711..1863 | - | 153 | WP_042468253.1 | Hok/Gef family protein | - |
| QDU35_RS22890 (QDU35_22890) | 2371..2868 | - | 498 | WP_042468254.1 | hypothetical protein | - |
| QDU35_RS22895 (QDU35_22895) | 2887..3201 | - | 315 | WP_225854525.1 | hypothetical protein | - |
| QDU35_RS22900 (QDU35_22900) | 3298..4263 | - | 966 | WP_042468256.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QDU35_RS22905 (QDU35_22905) | 4253..4651 | - | 399 | WP_042468273.1 | DUF6088 family protein | Antitoxin |
| QDU35_RS22910 (QDU35_22910) | 5588..6034 | + | 447 | WP_042468257.1 | DNA repair protein RadC | - |
| QDU35_RS22915 (QDU35_22915) | 6074..6436 | + | 363 | WP_042468258.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..70945 | 70945 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 322 a.a. Molecular weight: 36419.60 Da Isoelectric Point: 5.4150
>T278308 WP_042468256.1 NZ_CP122988:c4263-3298 [Aeromonas salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I
Download Length: 966 bp
Antitoxin
Download Length: 133 a.a. Molecular weight: 14761.36 Da Isoelectric Point: 11.0142
>AT278308 WP_042468273.1 NZ_CP122988:c4651-4253 [Aeromonas salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA
Download Length: 399 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A807ZF23 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A807ZF76 |