278306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 496275..496915 Replicon chromosome
Accession NZ_CP122987
Organism Aeromonas salmonicida strain JNG

Toxin (Protein)


Gene name vagD Uniprot ID A0A807Z4U5
Locus tag QDU35_RS02445 Protein ID WP_005320982.1
Coordinates 496275..496688 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807Z5T0
Locus tag QDU35_RS02450 Protein ID WP_005320985.1
Coordinates 496685..496915 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU35_RS02420 (QDU35_02420) 492650..493267 + 618 WP_225854306.1 subclass B2 metallo-beta-lactamase -
QDU35_RS02425 (QDU35_02425) 493415..494332 + 918 WP_088814123.1 IS5-like element ISAs4 family transposase -
QDU35_RS02430 (QDU35_02430) 494567..495484 + 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
QDU35_RS02435 (QDU35_02435) 495488..495808 - 321 WP_232479382.1 hypothetical protein -
QDU35_RS02440 (QDU35_02440) 495844..496197 - 354 WP_017413138.1 hypothetical protein -
QDU35_RS02445 (QDU35_02445) 496275..496688 - 414 WP_005320982.1 PIN domain-containing protein Toxin
QDU35_RS02450 (QDU35_02450) 496685..496915 - 231 WP_005320985.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QDU35_RS02455 (QDU35_02455) 496984..497289 - 306 WP_225854310.1 integrase -
QDU35_RS02460 (QDU35_02460) 497283..497672 - 390 WP_139403308.1 site-specific integrase -
QDU35_RS02465 (QDU35_02465) 498089..499006 - 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
QDU35_RS02475 (QDU35_02475) 501161..501496 + 336 WP_157668971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 491179..502554 11375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14935.23 Da        Isoelectric Point: 5.7146

>T278306 WP_005320982.1 NZ_CP122987:c496688-496275 [Aeromonas salmonicida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH

Download         Length: 414 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8699.88 Da        Isoelectric Point: 4.7419

>AT278306 WP_005320985.1 NZ_CP122987:c496915-496685 [Aeromonas salmonicida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807Z4U5

Antitoxin

Source ID Structure
AlphaFold DB A0A807Z5T0

References