Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 734973..735604 Replicon chromosome
Accession NZ_CP122962
Organism Agrobacterium tumefaciens strain CFBP5506

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CFBP5506_RS03655 Protein ID WP_080790996.1
Coordinates 735206..735604 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A420GCG3
Locus tag CFBP5506_RS03650 Protein ID WP_031233980.1
Coordinates 734973..735206 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5506_RS03625 (CFBP5506_03625) 729978..730214 + 237 WP_003502080.1 acyl carrier protein -
CFBP5506_RS03630 (CFBP5506_03630) 730465..731727 + 1263 WP_080791000.1 beta-ketoacyl-ACP synthase II -
CFBP5506_RS03635 (CFBP5506_03635) 732036..733256 + 1221 WP_080790999.1 endolytic transglycosylase MltG -
CFBP5506_RS03640 (CFBP5506_03640) 733324..734211 + 888 WP_080790998.1 YicC/YloC family endoribonuclease -
CFBP5506_RS03645 (CFBP5506_03645) 734216..734878 + 663 WP_080790997.1 guanylate kinase -
CFBP5506_RS03650 (CFBP5506_03650) 734973..735206 + 234 WP_031233980.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBP5506_RS03655 (CFBP5506_03655) 735206..735604 + 399 WP_080790996.1 tRNA(fMet)-specific endonuclease VapC Toxin
CFBP5506_RS03660 (CFBP5506_03660) 735621..736454 - 834 WP_080790995.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CFBP5506_RS03665 (CFBP5506_03665) 736454..737476 - 1023 WP_080790994.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
CFBP5506_RS03670 (CFBP5506_03670) 737502..738449 - 948 WP_080790993.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14927.20 Da        Isoelectric Point: 6.2251

>T278305 WP_080790996.1 NZ_CP122962:735206-735604 [Agrobacterium tumefaciens]
MLTYMLDTNICIYVMKTYPPELREKFNDLADQLCISSITLGELYYGAEKSVRRQENISAIENFTARLEVLPFADKGAAHY
GQIRAELTKVGTPCGVHDMQIGGHARSEGLIVVTNNMREFIRMPGLRAENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8649.92 Da        Isoelectric Point: 5.7974

>AT278305 WP_031233980.1 NZ_CP122962:734973-735206 [Agrobacterium tumefaciens]
MATSTVFISNRSQAVRLPKAVAFPDDVHKVDVLKIGLARVIVPQGKRWDDLFLTGPRATDDFLSVREEPALDEREPF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A420GCG3

References