Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 573837..574462 Replicon chromosome
Accession NZ_CP122962
Organism Agrobacterium tumefaciens strain CFBP5506

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFBP5506_RS02825 Protein ID WP_080791104.1
Coordinates 574103..574462 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A420FBH4
Locus tag CFBP5506_RS02820 Protein ID WP_059753836.1
Coordinates 573837..574103 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5506_RS02800 (CFBP5506_02800) 569312..570136 + 825 WP_080791107.1 class D beta-lactamase -
CFBP5506_RS02805 (CFBP5506_02805) 570513..573095 + 2583 WP_162927402.1 heavy metal translocating P-type ATPase -
CFBP5506_RS02810 (CFBP5506_02810) 573092..573514 + 423 WP_080791106.1 Cu(I)-responsive transcriptional regulator -
CFBP5506_RS02815 (CFBP5506_02815) 573567..573767 + 201 WP_080791105.1 heavy-metal-associated domain-containing protein -
CFBP5506_RS02820 (CFBP5506_02820) 573837..574103 + 267 WP_059753836.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CFBP5506_RS02825 (CFBP5506_02825) 574103..574462 + 360 WP_080791104.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFBP5506_RS02830 (CFBP5506_02830) 574483..574731 - 249 WP_077982678.1 hypothetical protein -
CFBP5506_RS02835 (CFBP5506_02835) 574909..576306 + 1398 WP_169538621.1 MFS transporter -
CFBP5506_RS02840 (CFBP5506_02840) 576324..576497 - 174 WP_077982677.1 hypothetical protein -
CFBP5506_RS02845 (CFBP5506_02845) 576566..578281 - 1716 WP_121459694.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12841.93 Da        Isoelectric Point: 7.7513

>T278304 WP_080791104.1 NZ_CP122962:574103-574462 [Agrobacterium tumefaciens]
MVRSQVPKRGDVYLVDLNPVIGSEISDEHRCIVITPREINAVGLCLVVPVNTGGLFTRRAGLAVNISGHKTTGVALCNQV
RSMDIVARASQKKAKYIETLDDATIDEIVGRVISMIDPA

Download         Length: 360 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9424.90 Da        Isoelectric Point: 4.5983

>AT278304 WP_059753836.1 NZ_CP122962:573837-574103 [Agrobacterium tumefaciens]
MTVTTRIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRQEKKRFTLAELLEGADEVAALNASAREWDEA
PPVGKEAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A420FBH4

References