Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 578766..579390 Replicon chromosome
Accession NZ_CP122951
Organism Helicobacter pylori strain BS26

Toxin (Protein)


Gene name relE Uniprot ID A0A2A6UH71
Locus tag QAD59_RS02815 Protein ID WP_025455067.1
Coordinates 579124..579390 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QAD59_RS02810 Protein ID WP_286490397.1
Coordinates 578766..579143 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAD59_RS02785 (QAD59_02790) 574001..575113 + 1113 WP_286490394.1 hydrogenase formation protein HypD -
QAD59_RS02790 (QAD59_02795) 575064..575585 - 522 WP_286490395.1 hypothetical protein -
QAD59_RS02805 (QAD59_02810) 576092..578314 + 2223 WP_286490396.1 Hop family adhesin BabA -
QAD59_RS02810 (QAD59_02815) 578766..579143 + 378 WP_286490397.1 hypothetical protein Antitoxin
QAD59_RS02815 (QAD59_02820) 579124..579390 + 267 WP_025455067.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
QAD59_RS02820 (QAD59_02825) 579495..580019 - 525 WP_001120211.1 acyl-CoA thioesterase -
QAD59_RS02825 (QAD59_02830) 580160..581002 + 843 WP_286490399.1 SDR family oxidoreductase -
QAD59_RS02830 (QAD59_02835) 580995..581975 + 981 WP_000921452.1 iron ABC transporter permease -
QAD59_RS02835 (QAD59_02840) 581975..582742 + 768 WP_000242366.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10303.17 Da        Isoelectric Point: 9.6292

>T278293 WP_025455067.1 NZ_CP122951:579124-579390 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14806.82 Da        Isoelectric Point: 9.0112

>AT278293 WP_286490397.1 NZ_CP122951:578766-579143 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLERKIKKMQNDRTSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6UH71

Antitoxin

Source ID Structure

References