Detailed information of TA system TA278292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 19798..20989
• Replicon: chromosome
• Accession: NZ_CP122951
• Organism: Helicobacter pylori strain BS26

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: QAD59_RS00080
• Protein ID: WP_140446210.1
• Coordinates: 20225..20989 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: QAD59_RS00075
• Protein ID: WP_120824146.1
• Coordinates: 19798..20235 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QAD59_RS00065 (QAD59_00065)	18337..18996	+	660	WP_286490105.1	RNA-directed DNA polymerase	-
QAD59_RS00070 (QAD59_00070)	19054..19572	+	519	WP_286490106.1	hypothetical protein	-
QAD59_RS00075 (QAD59_00075)	19798..20235	+	438	WP_120824146.1	Panacea domain-containing protein	Antitoxin
QAD59_RS00080 (QAD59_00080)	20225..20989	+	765	WP_140446210.1	hypothetical protein	Toxin
QAD59_RS00085 (QAD59_00085)	21211..22398	-	1188	WP_180656933.1	transcription termination factor NusA	-
QAD59_RS00090 (QAD59_00090)	22493..23653	-	1161	WP_286490107.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29805.00 Da
• Isoelectric Point: 8.8819

>T278292 WP_140446210.1 NZ_CP122951:20225-20989 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEKGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLIVTILFVIGFC
GELHIIQRLASKYF

Nucleotide

• Length: 765 bp

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17300.42 Da
• Isoelectric Point: 6.1265

>AT278292 WP_120824146.1 NZ_CP122951:19798-20235 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp