Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parE_1-relB/RelE(toxin) |
Location | 1145376..1145823 | Replicon | chromosome |
Accession | NC_017911 | ||
Organism | Pseudomonas fluorescens A506 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A854B692 |
Locus tag | PFLA506_RS27470 | Protein ID | WP_014717051.1 |
Coordinates | 1145554..1145823 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0W0ND88 |
Locus tag | PFLA506_RS05040 | Protein ID | WP_014717050.1 |
Coordinates | 1145376..1145564 (+) | Length | 63 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PFLA506_RS05015 | 1140915..1142246 | + | 1332 | WP_014717046.1 | aromatic acid/H+ symport family MFS transporter | - |
PFLA506_RS05020 | 1142232..1143035 | - | 804 | WP_014717047.1 | tetratricopeptide repeat protein | - |
PFLA506_RS05025 | 1143223..1144242 | + | 1020 | WP_014717048.1 | Glu/Leu/Phe/Val dehydrogenase | - |
PFLA506_RS05030 | 1144298..1144558 | - | 261 | WP_003188807.1 | YebG family protein | - |
PFLA506_RS05035 | 1144979..1145224 | + | 246 | WP_014717049.1 | hypothetical protein | - |
PFLA506_RS05040 | 1145376..1145564 | + | 189 | WP_014717050.1 | hypothetical protein | Antitoxin |
PFLA506_RS27470 | 1145554..1145823 | + | 270 | WP_014717051.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
PFLA506_RS05045 | 1145993..1146481 | + | 489 | WP_014717052.1 | phosphate-starvation-inducible PsiE family protein | - |
PFLA506_RS05050 | 1146478..1146795 | - | 318 | WP_014717053.1 | DUF3509 domain-containing protein | - |
PFLA506_RS05055 | 1147061..1148350 | - | 1290 | WP_014717054.1 | HAAAP family serine/threonine permease | - |
PFLA506_RS05060 | 1148412..1149788 | - | 1377 | WP_014717055.1 | L-serine ammonia-lyase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10381.24 Da Isoelectric Point: 10.9886
>T27829 WP_014717051.1 NC_017911:1145554-1145823 [Pseudomonas fluorescens A506]
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP
Download Length: 270 bp
>T27829 NC_017911:1145554-1145823 [Pseudomonas fluorescens A506]
ATGCTGATTGAATGGCTGCCCGCAGCGCGGGTAGAACTCCGGCAAATTATTGAGTACCTCAGTCATCGTAATCCTGTAGC
AGCGCTTGAGCTTAAGCGATCAATCGAAGCTTCAGTGCTTGCCCTCTCGCGCAGACCCCATCTTTACCGCCCCGGCAGAA
TCGGCGGAACACGAGAGATGGTGGTACATCCGAATTATCTGGTTGTATACAAAGTGACAGACAATATTCGGATTCTCTCG
GTTTTACACGCACGCCAGCGATATCCTTGA
ATGCTGATTGAATGGCTGCCCGCAGCGCGGGTAGAACTCCGGCAAATTATTGAGTACCTCAGTCATCGTAATCCTGTAGC
AGCGCTTGAGCTTAAGCGATCAATCGAAGCTTCAGTGCTTGCCCTCTCGCGCAGACCCCATCTTTACCGCCCCGGCAGAA
TCGGCGGAACACGAGAGATGGTGGTACATCCGAATTATCTGGTTGTATACAAAGTGACAGACAATATTCGGATTCTCTCG
GTTTTACACGCACGCCAGCGATATCCTTGA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6884.55 Da Isoelectric Point: 4.0061
>AT27829 WP_014717050.1 NC_017911:1145376-1145564 [Pseudomonas fluorescens A506]
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD
Download Length: 189 bp
>AT27829 NC_017911:1145376-1145564 [Pseudomonas fluorescens A506]
ATGGACACTTCCTTTTCCTCAGGTATCCAAGCAGATATCGAAGAGCAGGCTGACAGCTACGACCGCTGGTTTCGCGCGAG
AGTGCAGGCCGCTCTTGATGACCCAAGCCCTGGCATTCCTCACGACGAGGTGATGGCCGAGATGCAAGCGCTGATCGAAT
CTAAACTCAAGAAAGGCGATGCTGATTGA
ATGGACACTTCCTTTTCCTCAGGTATCCAAGCAGATATCGAAGAGCAGGCTGACAGCTACGACCGCTGGTTTCGCGCGAG
AGTGCAGGCCGCTCTTGATGACCCAAGCCCTGGCATTCCTCACGACGAGGTGATGGCCGAGATGCAAGCGCTGATCGAAT
CTAAACTCAAGAAAGGCGATGCTGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A854B692 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0ND88 |