Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE_1-relB/RelE(toxin)
Location 1145376..1145823 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A854B692
Locus tag PFLA506_RS27470 Protein ID WP_014717051.1
Coordinates 1145554..1145823 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0ND88
Locus tag PFLA506_RS05040 Protein ID WP_014717050.1
Coordinates 1145376..1145564 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS05015 1140915..1142246 + 1332 WP_014717046.1 aromatic acid/H+ symport family MFS transporter -
PFLA506_RS05020 1142232..1143035 - 804 WP_014717047.1 tetratricopeptide repeat protein -
PFLA506_RS05025 1143223..1144242 + 1020 WP_014717048.1 Glu/Leu/Phe/Val dehydrogenase -
PFLA506_RS05030 1144298..1144558 - 261 WP_003188807.1 YebG family protein -
PFLA506_RS05035 1144979..1145224 + 246 WP_014717049.1 hypothetical protein -
PFLA506_RS05040 1145376..1145564 + 189 WP_014717050.1 hypothetical protein Antitoxin
PFLA506_RS27470 1145554..1145823 + 270 WP_014717051.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFLA506_RS05045 1145993..1146481 + 489 WP_014717052.1 phosphate-starvation-inducible PsiE family protein -
PFLA506_RS05050 1146478..1146795 - 318 WP_014717053.1 DUF3509 domain-containing protein -
PFLA506_RS05055 1147061..1148350 - 1290 WP_014717054.1 HAAAP family serine/threonine permease -
PFLA506_RS05060 1148412..1149788 - 1377 WP_014717055.1 L-serine ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10381.24 Da        Isoelectric Point: 10.9886

>T27829 WP_014717051.1 NC_017911:1145554-1145823 [Pseudomonas fluorescens A506]
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP

Download         Length: 270 bp

>T27829 NC_017911:1145554-1145823 [Pseudomonas fluorescens A506]
ATGCTGATTGAATGGCTGCCCGCAGCGCGGGTAGAACTCCGGCAAATTATTGAGTACCTCAGTCATCGTAATCCTGTAGC
AGCGCTTGAGCTTAAGCGATCAATCGAAGCTTCAGTGCTTGCCCTCTCGCGCAGACCCCATCTTTACCGCCCCGGCAGAA
TCGGCGGAACACGAGAGATGGTGGTACATCCGAATTATCTGGTTGTATACAAAGTGACAGACAATATTCGGATTCTCTCG
GTTTTACACGCACGCCAGCGATATCCTTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6884.55 Da        Isoelectric Point: 4.0061

>AT27829 WP_014717050.1 NC_017911:1145376-1145564 [Pseudomonas fluorescens A506]
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD

Download         Length: 189 bp

>AT27829 NC_017911:1145376-1145564 [Pseudomonas fluorescens A506]
ATGGACACTTCCTTTTCCTCAGGTATCCAAGCAGATATCGAAGAGCAGGCTGACAGCTACGACCGCTGGTTTCGCGCGAG
AGTGCAGGCCGCTCTTGATGACCCAAGCCCTGGCATTCCTCACGACGAGGTGATGGCCGAGATGCAAGCGCTGATCGAAT
CTAAACTCAAGAAAGGCGATGCTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854B692

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0ND88

References