Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 36204..36751 Replicon plasmid unnamed5
Accession NZ_CP122943
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDX07_RS26055 Protein ID WP_244461648.1
Coordinates 36473..36751 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2H4TKA5
Locus tag QDX07_RS26050 Protein ID WP_000079937.1
Coordinates 36204..36473 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS26025 (31745) 31745..32335 + 591 WP_001375082.1 DUF2726 domain-containing protein -
QDX07_RS26030 (32575) 32575..32823 + 249 WP_000083839.1 replication regulatory protein RepA -
QDX07_RS26035 (33068) 33068..33142 + 75 WP_001365705.1 RepA leader peptide Tap -
QDX07_RS26040 (33135) 33135..33992 + 858 WP_042634321.1 incFII family plasmid replication initiator RepA -
QDX07_RS26045 (34991) 34991..36028 + 1038 WP_032083970.1 DNA-binding protein -
QDX07_RS26050 (36204) 36204..36473 + 270 WP_000079937.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDX07_RS26055 (36473) 36473..36751 + 279 WP_244461648.1 type II toxin-antitoxin system toxin YacB Toxin
QDX07_RS26060 (37060) 37060..38202 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDX07_RS26065 (38175) 38175..38279 + 105 Protein_41 hypothetical protein -
QDX07_RS26070 (38291) 38291..38596 + 306 WP_000482654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..69294 69294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10732.29 Da        Isoelectric Point: 8.4615

>T278283 WP_244461648.1 NZ_CP122943:36473-36751 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLTAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10174.56 Da        Isoelectric Point: 10.1760

>AT278283 WP_000079937.1 NZ_CP122943:36204-36473 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4TKA5

References