Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4370877..4371453 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDX07_RS21565 Protein ID WP_001297643.1
Coordinates 4371166..4371453 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDX07_RS21560 Protein ID WP_000063160.1
Coordinates 4370877..4371179 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS21545 (4367473) 4367473..4369623 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDX07_RS21550 (4369673) 4369673..4369876 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDX07_RS21555 (4369887) 4369887..4370843 + 957 WP_001297640.1 GTPase -
QDX07_RS21560 (4370877) 4370877..4371179 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDX07_RS21565 (4371166) 4371166..4371453 - 288 WP_001297643.1 BrnT family toxin Toxin
QDX07_RS21570 (4371652) 4371652..4372349 - 698 Protein_4223 IS1 family transposase -
QDX07_RS21575 (4372406) 4372406..4372501 + 96 Protein_4224 dienelactone hydrolase family protein -
QDX07_RS21580 (4372647) 4372647..4373879 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDX07_RS21585 (4373920) 4373920..4375200 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T278278 WP_001297643.1 NZ_CP122938:c4371453-4371166 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT278278 WP_000063160.1 NZ_CP122938:c4371179-4370877 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References