Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3785836..3786454 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX07_RS18755 Protein ID WP_001291435.1
Coordinates 3786236..3786454 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX07_RS18750 Protein ID WP_000344800.1
Coordinates 3785836..3786210 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS18740 (3780925) 3780925..3782118 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX07_RS18745 (3782141) 3782141..3785290 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDX07_RS18750 (3785836) 3785836..3786210 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX07_RS18755 (3786236) 3786236..3786454 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX07_RS18760 (3786626) 3786626..3787177 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX07_RS18765 (3787293) 3787293..3787763 + 471 WP_063085325.1 YlaC family protein -
QDX07_RS18770 (3787927) 3787927..3789477 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX07_RS18775 (3789519) 3789519..3789872 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX07_RS18785 (3790251) 3790251..3790562 + 312 WP_000409911.1 MGMT family protein -
QDX07_RS18790 (3790593) 3790593..3791165 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278275 WP_001291435.1 NZ_CP122938:3786236-3786454 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278275 WP_000344800.1 NZ_CP122938:3785836-3786210 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References