Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2557253..2557891 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDX07_RS12495 Protein ID WP_063085535.1
Coordinates 2557715..2557891 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX07_RS12490 Protein ID WP_001270286.1
Coordinates 2557253..2557669 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS12470 (2552405) 2552405..2553346 - 942 WP_063085538.1 ABC transporter permease -
QDX07_RS12475 (2553347) 2553347..2554360 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDX07_RS12480 (2554378) 2554378..2555523 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDX07_RS12485 (2555768) 2555768..2557174 - 1407 WP_063085536.1 PLP-dependent aminotransferase family protein -
QDX07_RS12490 (2557253) 2557253..2557669 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX07_RS12495 (2557715) 2557715..2557891 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX07_RS12500 (2558113) 2558113..2558343 + 231 WP_000494244.1 YncJ family protein -
QDX07_RS12505 (2558435) 2558435..2560396 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX07_RS12510 (2560469) 2560469..2561005 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDX07_RS12515 (2561097) 2561097..2562267 + 1171 Protein_2450 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T278269 WP_063085535.1 NZ_CP122938:c2557891-2557715 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278269 WP_001270286.1 NZ_CP122938:c2557669-2557253 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References