Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2458342..2459930 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDX07_RS12055 Protein ID WP_063085289.1
Coordinates 2458608..2459930 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDX07_RS12050 Protein ID WP_001296726.1
Coordinates 2458342..2458608 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS12050 (2458342) 2458342..2458608 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDX07_RS12055 (2458608) 2458608..2459930 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDX07_RS12060 (2460328) 2460328..2461225 - 898 Protein_2359 LysR substrate-binding domain-containing protein -
QDX07_RS12065 (2461365) 2461365..2461673 + 309 WP_001221046.1 hypothetical protein -
QDX07_RS12070 (2461682) 2461682..2462371 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDX07_RS12075 (2462433) 2462433..2463380 + 948 WP_063085290.1 aldo/keto reductase -
QDX07_RS12080 (2463483) 2463483..2463638 + 156 WP_001327998.1 hypothetical protein -
QDX07_RS12085 (2463598) 2463598..2464017 + 420 WP_001314733.1 amidohydrolase family protein -
QDX07_RS12090 (2464007) 2464007..2464159 + 153 WP_001314732.1 amidohydrolase family protein -
QDX07_RS12095 (2464309) 2464309..2464880 + 572 Protein_2366 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T278268 WP_063085289.1 NZ_CP122938:2458608-2459930 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT278268 WP_001296726.1 NZ_CP122938:2458342-2458608 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References