Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4258035..4258532 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX05_RS21125 Protein ID WP_001173343.1
Coordinates 4258035..4258208 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX05_RS21130 Protein ID WP_000398619.1
Coordinates 4258236..4258532 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS21115 (4254705) 4254705..4256162 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDX05_RS21120 (4256399) 4256399..4257916 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX05_RS21125 (4258035) 4258035..4258208 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX05_RS21130 (4258236) 4258236..4258532 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX05_RS21135 (4258758) 4258758..4259030 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX05_RS21140 (4259042) 4259042..4259272 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX05_RS21145 (4259453) 4259453..4261084 + 1632 WP_001216477.1 sensor histidine kinase -
QDX05_RS21150 (4261081) 4261081..4261800 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278251 WP_001173343.1 NZ_CP122929:c4258208-4258035 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278251 WP_000398619.1 NZ_CP122929:c4258532-4258236 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References