Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4027247..4027823 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDX05_RS19945 Protein ID WP_001297643.1
Coordinates 4027536..4027823 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDX05_RS19940 Protein ID WP_000063156.1
Coordinates 4027247..4027549 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS19925 (4023843) 4023843..4025993 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDX05_RS19930 (4026043) 4026043..4026246 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDX05_RS19935 (4026257) 4026257..4027213 + 957 WP_001297640.1 GTPase -
QDX05_RS19940 (4027247) 4027247..4027549 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDX05_RS19945 (4027536) 4027536..4027823 - 288 WP_001297643.1 BrnT family toxin Toxin
QDX05_RS19950 (4028022) 4028022..4028719 - 698 Protein_3900 IS1 family transposase -
QDX05_RS19955 (4028776) 4028776..4028871 + 96 Protein_3901 dienelactone hydrolase family protein -
QDX05_RS19960 (4029017) 4029017..4030249 + 1233 WP_001380906.1 multidrug efflux MFS transporter MdtM -
QDX05_RS19965 (4030290) 4030290..4031570 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T278250 WP_001297643.1 NZ_CP122929:c4027823-4027536 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT278250 WP_000063156.1 NZ_CP122929:c4027549-4027247 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References