Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512653..3513271 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX05_RS17480 Protein ID WP_001291435.1
Coordinates 3513053..3513271 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX05_RS17475 Protein ID WP_000344800.1
Coordinates 3512653..3513027 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS17465 (3507742) 3507742..3508935 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX05_RS17470 (3508958) 3508958..3512107 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX05_RS17475 (3512653) 3512653..3513027 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX05_RS17480 (3513053) 3513053..3513271 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX05_RS17485 (3513443) 3513443..3513994 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX05_RS17490 (3514110) 3514110..3514580 + 471 WP_000136192.1 YlaC family protein -
QDX05_RS17495 (3514744) 3514744..3516294 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX05_RS17500 (3516336) 3516336..3516689 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX05_RS17510 (3517068) 3517068..3517379 + 312 WP_000409911.1 MGMT family protein -
QDX05_RS17515 (3517410) 3517410..3517982 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278247 WP_001291435.1 NZ_CP122929:3513053-3513271 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278247 WP_000344800.1 NZ_CP122929:3512653-3513027 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References