Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2447612..2448250 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag QDX05_RS12185 Protein ID WP_001447010.1
Coordinates 2448074..2448250 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX05_RS12180 Protein ID WP_001270286.1
Coordinates 2447612..2448028 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS12160 (2442765) 2442765..2443706 - 942 WP_001251304.1 ABC transporter permease -
QDX05_RS12165 (2443707) 2443707..2444720 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDX05_RS12170 (2444738) 2444738..2445883 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDX05_RS12175 (2446128) 2446128..2447533 - 1406 Protein_2383 PLP-dependent aminotransferase family protein -
QDX05_RS12180 (2447612) 2447612..2448028 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX05_RS12185 (2448074) 2448074..2448250 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX05_RS12190 (2448472) 2448472..2448702 + 231 WP_000494244.1 YncJ family protein -
QDX05_RS12195 (2448794) 2448794..2450755 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX05_RS12200 (2450828) 2450828..2451364 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDX05_RS12205 (2451456) 2451456..2452631 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T278246 WP_001447010.1 NZ_CP122929:c2448250-2448074 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278246 WP_001270286.1 NZ_CP122929:c2448028-2447612 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References