278244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2309260..2309786 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QDX05_RS11480 Protein ID WP_000323025.1
Coordinates 2309499..2309786 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QDX05_RS11475 Protein ID WP_000534858.1
Coordinates 2309260..2309499 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS11440 (2304447) 2304447..2304569 - 123 Protein_2236 transposase -
QDX05_RS11445 (2304812) 2304812..2305233 + 422 Protein_2237 hypothetical protein -
QDX05_RS11455 (2306666) 2306666..2307688 + 1023 Protein_2239 ISNCY family transposase -
QDX05_RS11460 (2307809) 2307809..2307958 + 150 WP_011443592.1 protein YdfW -
QDX05_RS11465 (2308395) 2308395..2308727 - 333 WP_001301033.1 FlxA-like family protein -
QDX05_RS11470 (2308930) 2308930..2309235 - 306 WP_001326990.1 protein YdfV -
QDX05_RS11475 (2309260) 2309260..2309499 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QDX05_RS11480 (2309499) 2309499..2309786 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QDX05_RS11485 (2309858) 2309858..2310013 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QDX05_RS11490 (2310230) 2310230..2310481 + 252 WP_000980994.1 protein Rem -
QDX05_RS11495 (2310548) 2310548..2310826 + 279 WP_012304870.1 hypothetical protein -
QDX05_RS11500 (2310828) 2310828..2311876 + 1049 Protein_2248 DUF968 domain-containing protein -
QDX05_RS11505 (2311890) 2311890..2312642 + 753 WP_001047135.1 antitermination protein -
QDX05_RS11510 (2312920) 2312920..2313009 - 90 WP_120795389.1 hypothetical protein -
QDX05_RS11515 (2313064) 2313064..2313276 - 213 WP_000087756.1 cold shock-like protein CspF -
QDX05_RS11520 (2313577) 2313577..2313792 + 216 WP_000066484.1 cold shock-like protein CspB -
QDX05_RS11525 (2314156) 2314156..2314326 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
QDX05_RS11530 (2314546) 2314546..2314761 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2297568..2324970 27402


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T278244 WP_000323025.1 NZ_CP122929:2309499-2309786 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT278244 WP_000534858.1 NZ_CP122929:2309260-2309499 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References