Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52909..53444 Replicon plasmid unnamed4
Accession NZ_CP122927
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDX14_RS27365 Protein ID WP_001270421.1
Coordinates 53157..53444 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag QDX14_RS27360 Protein ID WP_001132895.1
Coordinates 52909..53160 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS27330 (47967) 47967..49136 + 1170 WP_282856699.1 RNA-guided endonuclease TnpB family protein -
QDX14_RS27335 (49173) 49173..49598 - 426 WP_024193300.1 antirestriction protein -
QDX14_RS27340 (49672) 49672..49845 + 174 Protein_63 DUF4113 domain-containing protein -
QDX14_RS27345 (49985) 49985..50947 - 963 WP_032084392.1 ParB family protein -
QDX14_RS27350 (50944) 50944..52149 - 1206 WP_032084391.1 AAA family ATPase -
QDX14_RS27355 (52523) 52523..52735 + 213 WP_032084390.1 hypothetical protein -
QDX14_RS27360 (52909) 52909..53160 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX14_RS27365 (53157) 53157..53444 + 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX14_RS27370 (53446) 53446..53857 + 412 Protein_69 DDE-type integrase/transposase/recombinase -
QDX14_RS27375 (54501) 54501..55478 + 978 WP_000361618.1 RepB family plasmid replication initiator protein -
QDX14_RS27380 (55721) 55721..56461 - 741 WP_001066941.1 tyrosine-type recombinase/integrase -
QDX14_RS27385 (56648) 56648..57835 - 1188 WP_000937592.1 IS91 family transposase -
QDX14_RS27390 (57835) 57835..58200 - 366 WP_000091308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyD 1..107634 107634
- flank IS/Tn - - 47967..49136 1169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T278232 WP_001270421.1 NZ_CP122927:53157-53444 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT278232 WP_001132895.1 NZ_CP122927:52909-53160 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References