Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 25364..25989 Replicon plasmid unnamed4
Accession NZ_CP122927
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDX14_RS27185 Protein ID WP_000911317.1
Coordinates 25364..25762 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QDX14_RS27190 Protein ID WP_000450532.1
Coordinates 25762..25989 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS27155 (20564) 20564..20734 - 171 WP_227432179.1 hypothetical protein -
QDX14_RS27160 (21032) 21032..21463 - 432 Protein_27 transposase -
QDX14_RS27165 (21461) 21461..22495 + 1035 Protein_28 conjugal transfer protein TraG -
QDX14_RS27170 (22511) 22511..23008 + 498 WP_032084504.1 entry exclusion protein -
QDX14_RS27175 (23040) 23040..23771 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
QDX14_RS27180 (24022) 24022..25212 + 1191 Protein_31 type IV conjugative transfer system coupling protein TraD -
QDX14_RS27185 (25364) 25364..25762 - 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
QDX14_RS27190 (25762) 25762..25989 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDX14_RS27195 (26071) 26071..30305 + 4235 Protein_34 conjugative transfer relaxase/helicase TraI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyD 1..107634 107634
- flank IS/Tn - - 21032..21475 443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T278228 WP_000911317.1 NZ_CP122927:c25762-25364 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT278228 WP_000450532.1 NZ_CP122927:c25989-25762 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References