Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 50072..50619 Replicon plasmid unnamed3
Accession NZ_CP122926
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDX14_RS26755 Protein ID WP_001384452.1
Coordinates 50072..50350 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QDX14_RS26760 Protein ID WP_000079928.1
Coordinates 50350..50619 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS26730 (45468) 45468..46271 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
QDX14_RS26735 (46271) 46271..46390 + 120 Protein_59 aminoglycoside phosphotransferase family protein -
QDX14_RS26740 (46392) 46392..47453 + 1062 Protein_60 IS91-like element IS91 family transposase -
QDX14_RS26745 (48093) 48093..49280 + 1188 WP_000937612.1 IS91-like element IS91 family transposase -
QDX14_RS26750 (49469) 49469..50032 - 564 Protein_62 3'-5' exonuclease -
QDX14_RS26755 (50072) 50072..50350 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDX14_RS26760 (50350) 50350..50619 - 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDX14_RS26765 (50674) 50674..50832 - 159 WP_000841008.1 hypothetical protein -
QDX14_RS26770 (51528) 51528..52559 - 1032 WP_000907875.1 plasmid replication initiator RepA -
QDX14_RS26775 (53565) 53565..53795 + 231 WP_228772074.1 ash family protein -
QDX14_RS26780 (53713) 53713..54000 + 288 WP_000074849.1 conjugal transfer protein TraA -
QDX14_RS26785 (54442) 54442..54975 + 534 WP_001303319.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / sul2 / aph(3'')-Ib - 1..102470 102470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T278222 WP_001384452.1 NZ_CP122926:c50350-50072 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT278222 WP_000079928.1 NZ_CP122926:c50619-50350 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References