Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3851322..3851940 Replicon chromosome
Accession NZ_CP122923
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX14_RS19450 Protein ID WP_001291435.1
Coordinates 3851722..3851940 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX14_RS19445 Protein ID WP_000344800.1
Coordinates 3851322..3851696 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS19435 (3846411) 3846411..3847604 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX14_RS19440 (3847627) 3847627..3850776 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX14_RS19445 (3851322) 3851322..3851696 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX14_RS19450 (3851722) 3851722..3851940 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX14_RS19455 (3852112) 3852112..3852663 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX14_RS19460 (3852779) 3852779..3853249 + 471 WP_000136192.1 YlaC family protein -
QDX14_RS19465 (3853413) 3853413..3854963 + 1551 WP_094336394.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX14_RS19470 (3855005) 3855005..3855358 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX14_RS19480 (3855737) 3855737..3856048 + 312 WP_000409911.1 MGMT family protein -
QDX14_RS19485 (3856079) 3856079..3856651 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278217 WP_001291435.1 NZ_CP122923:3851722-3851940 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278217 WP_000344800.1 NZ_CP122923:3851322-3851696 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References