Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 939483..940137 Replicon chromosome
Accession NZ_CP122923
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDX14_RS04585 Protein ID WP_000244777.1
Coordinates 939730..940137 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDX14_RS04580 Protein ID WP_000354046.1
Coordinates 939483..939749 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS04560 (935452) 935452..936885 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
QDX14_RS04565 (936930) 936930..937241 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
QDX14_RS04570 (937405) 937405..938064 + 660 WP_000250274.1 hemolysin III family protein -
QDX14_RS04575 (938260) 938260..939240 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
QDX14_RS04580 (939483) 939483..939749 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDX14_RS04585 (939730) 939730..940137 + 408 WP_000244777.1 protein YgfX Toxin
QDX14_RS04590 (940177) 940177..940698 - 522 WP_001055874.1 flavodoxin FldB -
QDX14_RS04595 (940810) 940810..941706 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDX14_RS04600 (941731) 941731..942441 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDX14_RS04605 (942447) 942447..944180 + 1734 WP_032187585.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T278206 WP_000244777.1 NZ_CP122923:939730-940137 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278206 WP_000354046.1 NZ_CP122923:939483-939749 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References