278201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 43707..44208 Replicon plasmid unnamed5
Accession NZ_CP122885
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name TsxA Uniprot ID A0A6X6XTU7
Locus tag QDX09_RS27445 Protein ID WP_000702245.1
Coordinates 43707..43967 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag QDX09_RS27450 Protein ID WP_001132407.1
Coordinates 43957..44208 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS27410 (QDX09_27410) 39203..40390 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDX09_RS27415 (QDX09_27415) 40390..40755 - 366 WP_000124098.1 hypothetical protein -
QDX09_RS27420 (QDX09_27420) 41032..42219 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDX09_RS27425 (QDX09_27425) 42219..42584 - 366 WP_000124098.1 hypothetical protein -
QDX09_RS27430 (QDX09_27430) 42760..43083 + 324 WP_000432876.1 hypothetical protein -
QDX09_RS27435 (QDX09_27435) 43124..43333 + 210 WP_000866037.1 hypothetical protein -
QDX09_RS27440 (QDX09_27440) 43431..43655 + 225 WP_000814383.1 hypothetical protein -
QDX09_RS27445 (QDX09_27445) 43707..43967 + 261 WP_000702245.1 hypothetical protein Toxin
QDX09_RS27450 (QDX09_27450) 43957..44208 + 252 WP_001132407.1 transcriptional regulator Antitoxin
QDX09_RS27455 (QDX09_27455) 44758..45036 + 279 WP_000545938.1 hypothetical protein -
QDX09_RS27460 (QDX09_27460) 45424..45867 - 444 WP_000192626.1 hypothetical protein -
QDX09_RS27465 (QDX09_27465) 46164..46346 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
QDX09_RS27470 (QDX09_27470) 46371..46808 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
QDX09_RS27475 (QDX09_27475) 46939..47265 - 327 WP_000206697.1 hypothetical protein -
QDX09_RS27480 (QDX09_27480) 47262..47471 - 210 WP_000951714.1 hypothetical protein -
QDX09_RS27485 (QDX09_27485) 47473..47670 - 198 WP_001439049.1 hypothetical protein -
QDX09_RS27490 (QDX09_27490) 47994..48125 - 132 Protein_63 hypothetical protein -
QDX09_RS27495 (QDX09_27495) 48145..48852 - 708 WP_021503228.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..63267 63267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9818.23 Da        Isoelectric Point: 9.5163

>T278201 WP_000702245.1 NZ_CP122885:43707-43967 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT278201 WP_001132407.1 NZ_CP122885:43957-44208 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6X6XTU7

Antitoxin

Source ID Structure

References