Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 17954..18476 Replicon plasmid unnamed4
Accession NZ_CP122884
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag QDX09_RS26560 Protein ID WP_000220560.1
Coordinates 18195..18476 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QDX09_RS26555 Protein ID WP_000121743.1
Coordinates 17954..18205 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS26535 (13054) 13054..13905 + 852 Protein_18 transposase -
QDX09_RS26540 (13983) 13983..14348 + 366 WP_000124098.1 hypothetical protein -
QDX09_RS26545 (14348) 14348..15535 + 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDX09_RS26550 (15884) 15884..16720 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
QDX09_RS26555 (17954) 17954..18205 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QDX09_RS26560 (18195) 18195..18476 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX09_RS26565 (18859) 18859..20046 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDX09_RS26570 (20046) 20046..20411 - 366 WP_000124098.1 hypothetical protein -
QDX09_RS26575 (20493) 20493..21905 + 1413 Protein_26 DNA topoisomerase -
QDX09_RS26580 (22044) 22044..22307 + 264 WP_000063165.1 hypothetical protein -
QDX09_RS26585 (22479) 22479..22901 + 423 WP_001398192.1 hypothetical protein -
QDX09_RS26590 (23354) 23354..23449 + 96 WP_000609147.1 DinQ-like type I toxin DqlB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa / hlyC / hlyA / hlyB / hlyB / hlyD 1..123715 123715
- inside IScluster/Tn - estIa 25..20091 20066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T278199 WP_000220560.1 NZ_CP122884:18195-18476 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT278199 WP_000121743.1 NZ_CP122884:17954-18205 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References