Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 17998..18599 Replicon plasmid unnamed2
Accession NZ_CP122882
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag QDX09_RS25810 Protein ID WP_001216045.1
Coordinates 17998..18378 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDX09_RS25815 Protein ID WP_001190712.1
Coordinates 18378..18599 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS25785 (QDX09_25785) 13439..14923 - 1485 WP_000124150.1 terminase -
QDX09_RS25790 (QDX09_25790) 14923..16116 - 1194 WP_032153803.1 hypothetical protein -
QDX09_RS25795 (QDX09_25795) 16202..16654 - 453 WP_001326849.1 late promoter-activating protein -
QDX09_RS25800 (QDX09_25800) 16743..17786 - 1044 WP_148116453.1 DUF968 domain-containing protein -
QDX09_RS25805 (QDX09_25805) 17814..17993 - 180 WP_001436571.1 hypothetical protein -
QDX09_RS25810 (QDX09_25810) 17998..18378 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDX09_RS25815 (QDX09_25815) 18378..18599 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX09_RS25820 (QDX09_25820) 18782..20338 + 1557 WP_282862717.1 type I restriction-modification system subunit M -
QDX09_RS25825 (QDX09_25825) 20335..21555 + 1221 WP_282862718.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93572 93572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T278198 WP_001216045.1 NZ_CP122882:c18378-17998 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT278198 WP_001190712.1 NZ_CP122882:c18599-18378 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References