Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4574197..4574694 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX09_RS22885 Protein ID WP_001173343.1
Coordinates 4574197..4574370 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX09_RS22890 Protein ID WP_000398619.1
Coordinates 4574398..4574694 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS22875 (4570867) 4570867..4572324 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDX09_RS22880 (4572561) 4572561..4574078 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX09_RS22885 (4574197) 4574197..4574370 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX09_RS22890 (4574398) 4574398..4574694 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX09_RS22895 (4574921) 4574921..4575193 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX09_RS22900 (4575205) 4575205..4575435 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX09_RS22905 (4575616) 4575616..4577247 + 1632 WP_001216477.1 sensor histidine kinase -
QDX09_RS22910 (4577244) 4577244..4577963 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278193 WP_001173343.1 NZ_CP122880:c4574370-4574197 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278193 WP_000398619.1 NZ_CP122880:c4574694-4574398 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References