Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3823219..3823837 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX09_RS19240 Protein ID WP_001291435.1
Coordinates 3823619..3823837 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX09_RS19235 Protein ID WP_000344800.1
Coordinates 3823219..3823593 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS19225 (3818308) 3818308..3819501 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX09_RS19230 (3819524) 3819524..3822673 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX09_RS19235 (3823219) 3823219..3823593 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX09_RS19240 (3823619) 3823619..3823837 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX09_RS19245 (3824009) 3824009..3824560 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX09_RS19250 (3824676) 3824676..3825146 + 471 WP_000136192.1 YlaC family protein -
QDX09_RS19255 (3825310) 3825310..3826860 + 1551 WP_001372457.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX09_RS19260 (3826902) 3826902..3827255 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX09_RS19270 (3827634) 3827634..3827945 + 312 WP_000409911.1 MGMT family protein -
QDX09_RS19275 (3827976) 3827976..3828548 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278190 WP_001291435.1 NZ_CP122880:3823619-3823837 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278190 WP_000344800.1 NZ_CP122880:3823219-3823593 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References