Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2655239..2655877 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDX09_RS13235 Protein ID WP_000813794.1
Coordinates 2655701..2655877 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX09_RS13230 Protein ID WP_001270286.1
Coordinates 2655239..2655655 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS13210 (2650391) 2650391..2651332 - 942 WP_001251304.1 ABC transporter permease -
QDX09_RS13215 (2651333) 2651333..2652346 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDX09_RS13220 (2652364) 2652364..2653509 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDX09_RS13225 (2653754) 2653754..2655160 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDX09_RS13230 (2655239) 2655239..2655655 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX09_RS13235 (2655701) 2655701..2655877 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX09_RS13240 (2656099) 2656099..2656329 + 231 WP_000494244.1 YncJ family protein -
QDX09_RS13245 (2656421) 2656421..2658382 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX09_RS13250 (2658455) 2658455..2658991 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDX09_RS13255 (2659083) 2659083..2660258 + 1176 WP_282862205.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278188 WP_000813794.1 NZ_CP122880:c2655877-2655701 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278188 WP_001270286.1 NZ_CP122880:c2655655-2655239 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References