Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 957018..957672 | Replicon | chromosome |
Accession | NZ_CP122880 | ||
Organism | Escherichia coli strain ETEC1716 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | S1EEB2 |
Locus tag | QDX09_RS04735 | Protein ID | WP_000244777.1 |
Coordinates | 957265..957672 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | QDX09_RS04730 | Protein ID | WP_000354046.1 |
Coordinates | 957018..957284 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QDX09_RS04705 (952068) | 952068..952811 | + | 744 | WP_000951964.1 | SDR family oxidoreductase | - |
QDX09_RS04710 (952868) | 952868..954301 | - | 1434 | WP_001336277.1 | 6-phospho-beta-glucosidase BglA | - |
QDX09_RS04715 (954346) | 954346..954657 | + | 312 | WP_001182957.1 | N(4)-acetylcytidine aminohydrolase | - |
QDX09_RS04720 (954821) | 954821..955480 | + | 660 | WP_000250274.1 | hemolysin III family protein | - |
QDX09_RS04725 (955795) | 955795..956775 | - | 981 | WP_000886062.1 | tRNA-modifying protein YgfZ | - |
QDX09_RS04730 (957018) | 957018..957284 | + | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
QDX09_RS04735 (957265) | 957265..957672 | + | 408 | WP_000244777.1 | protein YgfX | Toxin |
QDX09_RS04740 (957712) | 957712..958233 | - | 522 | WP_001055874.1 | flavodoxin FldB | - |
QDX09_RS04745 (958345) | 958345..959241 | + | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
QDX09_RS04750 (959266) | 959266..959976 | + | 711 | WP_000715214.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
QDX09_RS04755 (959982) | 959982..961715 | + | 1734 | WP_000813200.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16031.96 Da Isoelectric Point: 11.5202
>T278179 WP_000244777.1 NZ_CP122880:957265-957672 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LFV7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QD57 |