Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 78091..78716 Replicon plasmid unnamed2
Accession NZ_CP122878
Organism Escherichia coli strain ETEC1717

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDX11_RS26335 Protein ID WP_000911317.1
Coordinates 78318..78716 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QDX11_RS26330 Protein ID WP_000450532.1
Coordinates 78091..78318 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX11_RS26325 (73775) 73775..78009 - 4235 Protein_86 conjugative transfer relaxase/helicase TraI -
QDX11_RS26330 (78091) 78091..78318 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDX11_RS26335 (78318) 78318..78716 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
QDX11_RS26340 (78868) 78868..80058 - 1191 Protein_89 type IV conjugative transfer system coupling protein TraD -
QDX11_RS26345 (80309) 80309..81040 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
QDX11_RS26350 (81072) 81072..81569 - 498 WP_032084504.1 entry exclusion protein -
QDX11_RS26355 (81585) 81585..82619 - 1035 Protein_92 conjugal transfer protein TraG -
QDX11_RS26360 (82617) 82617..83048 + 432 Protein_93 transposase -
QDX11_RS26365 (83346) 83346..83516 + 171 WP_227432179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102368 102368
- flank IS/Tn - - 82605..83048 443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T278173 WP_000911317.1 NZ_CP122878:78318-78716 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT278173 WP_000450532.1 NZ_CP122878:78091-78318 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References