Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52477..53012 Replicon plasmid unnamed2
Accession NZ_CP122878
Organism Escherichia coli strain ETEC1717

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDX11_RS26165 Protein ID WP_001270421.1
Coordinates 52477..52764 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag QDX11_RS26170 Protein ID WP_001132895.1
Coordinates 52761..53012 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX11_RS26140 (47712) 47712..48899 + 1188 WP_000937592.1 IS91 family transposase -
QDX11_RS26145 (49157) 49157..49354 - 198 Protein_50 ISL3 family transposase -
QDX11_RS26150 (49460) 49460..50200 + 741 WP_001066941.1 tyrosine-type recombinase/integrase -
QDX11_RS26155 (50443) 50443..51420 - 978 WP_000361618.1 RepB family plasmid replication initiator protein -
QDX11_RS26160 (52064) 52064..52475 - 412 Protein_53 DDE-type integrase/transposase/recombinase -
QDX11_RS26165 (52477) 52477..52764 - 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX11_RS26170 (52761) 52761..53012 - 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX11_RS26175 (53186) 53186..53398 - 213 WP_032084390.1 hypothetical protein -
QDX11_RS26180 (53772) 53772..54977 + 1206 WP_032084391.1 AAA family ATPase -
QDX11_RS26185 (54974) 54974..55936 + 963 WP_032084392.1 ParB family protein -
QDX11_RS26190 (56076) 56076..56249 - 174 Protein_59 DUF4113 domain-containing protein -
QDX11_RS26195 (56323) 56323..56748 + 426 WP_024193300.1 antirestriction protein -
QDX11_RS26200 (56785) 56785..57954 - 1170 WP_282856699.1 RNA-guided endonuclease TnpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102368 102368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T278169 WP_001270421.1 NZ_CP122878:c52764-52477 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT278169 WP_001132895.1 NZ_CP122878:c53012-52761 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References