Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 74473..75098 Replicon plasmid unnamed2
Accession NZ_CP122874
Organism Escherichia coli strain ETEC1718

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDX06_RS26275 Protein ID WP_000911317.1
Coordinates 74700..75098 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QDX06_RS26270 Protein ID WP_000450532.1
Coordinates 74473..74700 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX06_RS26265 (70157) 70157..74391 - 4235 Protein_81 conjugative transfer relaxase/helicase TraI -
QDX06_RS26270 (74473) 74473..74700 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDX06_RS26275 (74700) 74700..75098 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
QDX06_RS26280 (75250) 75250..76440 - 1191 Protein_84 type IV conjugative transfer system coupling protein TraD -
QDX06_RS26285 (76691) 76691..77422 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
QDX06_RS26290 (77454) 77454..77951 - 498 WP_032084504.1 entry exclusion protein -
QDX06_RS26295 (77967) 77967..79001 - 1035 Protein_87 conjugal transfer protein TraG -
QDX06_RS26300 (78999) 78999..79430 + 432 Protein_88 transposase -
QDX06_RS26305 (79728) 79728..79898 + 171 WP_227432179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102370 102370
- flank IS/Tn - - 78987..79430 443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T278153 WP_000911317.1 NZ_CP122874:74700-75098 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT278153 WP_000450532.1 NZ_CP122874:74473-74700 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References