Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52567..53102 Replicon plasmid unnamed2
Accession NZ_CP122874
Organism Escherichia coli strain ETEC1718

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QDX06_RS26145 Protein ID WP_001270421.1
Coordinates 52815..53102 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag QDX06_RS26140 Protein ID WP_001132895.1
Coordinates 52567..52818 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX06_RS26110 (47624) 47624..48793 + 1170 WP_282856699.1 RNA-guided endonuclease TnpB family protein -
QDX06_RS26115 (48830) 48830..49255 - 426 WP_024193300.1 antirestriction protein -
QDX06_RS26120 (49329) 49329..49502 + 174 Protein_52 DUF4113 domain-containing protein -
QDX06_RS26125 (49643) 49643..50605 - 963 WP_032084392.1 ParB family protein -
QDX06_RS26130 (50602) 50602..51807 - 1206 WP_032084391.1 AAA family ATPase -
QDX06_RS26135 (52181) 52181..52393 + 213 WP_032084390.1 hypothetical protein -
QDX06_RS26140 (52567) 52567..52818 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX06_RS26145 (52815) 52815..53102 + 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX06_RS26150 (53104) 53104..53515 + 412 Protein_58 DDE-type integrase/transposase/recombinase -
QDX06_RS26155 (54159) 54159..55136 + 978 WP_000361618.1 RepB family plasmid replication initiator protein -
QDX06_RS26160 (55379) 55379..56119 - 741 WP_001066941.1 tyrosine-type recombinase/integrase -
QDX06_RS26165 (56225) 56225..56422 + 198 Protein_61 ISL3 family transposase -
QDX06_RS26170 (56680) 56680..57867 - 1188 WP_000937592.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102370 102370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T278149 WP_001270421.1 NZ_CP122874:52815-53102 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT278149 WP_001132895.1 NZ_CP122874:52567-52818 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References