Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4620638..4621135 Replicon chromosome
Accession NZ_CP122872
Organism Escherichia coli strain ETEC1718

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX06_RS23195 Protein ID WP_001173343.1
Coordinates 4620638..4620811 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX06_RS23200 Protein ID WP_000398619.1
Coordinates 4620839..4621135 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX06_RS23185 (4617308) 4617308..4618765 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDX06_RS23190 (4619002) 4619002..4620519 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX06_RS23195 (4620638) 4620638..4620811 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX06_RS23200 (4620839) 4620839..4621135 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX06_RS23205 (4621361) 4621361..4621633 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX06_RS23210 (4621645) 4621645..4621875 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX06_RS23215 (4622056) 4622056..4623687 + 1632 WP_001216477.1 sensor histidine kinase -
QDX06_RS23220 (4623684) 4623684..4624403 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278146 WP_001173343.1 NZ_CP122872:c4620811-4620638 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278146 WP_000398619.1 NZ_CP122872:c4621135-4620839 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References