278126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4262384..4262881 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX04_RS20715 Protein ID WP_001173343.1
Coordinates 4262384..4262557 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX04_RS20720 Protein ID WP_000398619.1
Coordinates 4262585..4262881 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS20705 (4259054) 4259054..4260511 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
QDX04_RS20710 (4260748) 4260748..4262265 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX04_RS20715 (4262384) 4262384..4262557 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX04_RS20720 (4262585) 4262585..4262881 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX04_RS20725 (4263108) 4263108..4263380 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDX04_RS20730 (4263392) 4263392..4263622 - 231 WP_282843261.1 4Fe-4S mono-cluster protein YjdI -
QDX04_RS20735 (4263803) 4263803..4265434 + 1632 WP_001216486.1 sensor histidine kinase -
QDX04_RS20740 (4265431) 4265431..4266150 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278126 WP_001173343.1 NZ_CP122868:c4262557-4262384 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278126 WP_000398619.1 NZ_CP122868:c4262881-4262585 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References