278125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4159286..4159881 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag QDX04_RS20195 Protein ID WP_000239576.1
Coordinates 4159286..4159636 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QDX04_RS20200 Protein ID WP_001223208.1
Coordinates 4159630..4159881 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS20175 (4154732) 4154732..4155754 - 1023 WP_001296689.1 ABC transporter permease -
QDX04_RS20180 (4155768) 4155768..4157270 - 1503 WP_282843258.1 sugar ABC transporter ATP-binding protein -
QDX04_RS20185 (4157410) 4157410..4158366 - 957 WP_097447580.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDX04_RS20190 (4158676) 4158676..4159206 + 531 WP_000055075.1 inorganic diphosphatase -
QDX04_RS20195 (4159286) 4159286..4159636 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
QDX04_RS20200 (4159630) 4159630..4159881 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDX04_RS20205 (4160093) 4160093..4160434 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDX04_RS20210 (4160437) 4160437..4164216 - 3780 WP_282843259.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T278125 WP_000239576.1 NZ_CP122868:c4159636-4159286 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT278125 WP_001223208.1 NZ_CP122868:c4159881-4159630 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References