278124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4108371..4109706 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name sanaT Uniprot ID F4VMR9
Locus tag QDX04_RS19970 Protein ID WP_000342497.1
Coordinates 4108371..4109318 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A228Z6F8
Locus tag QDX04_RS19975 Protein ID WP_000152739.1
Coordinates 4109311..4109706 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS19940 (4104224) 4104224..4104940 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
QDX04_RS19945 (4104960) 4104960..4106066 + 1107 WP_001349986.1 N-acetylneuraminate epimerase -
QDX04_RS19950 (4106131) 4106131..4107111 + 981 WP_097447670.1 sialate O-acetylesterase -
QDX04_RS19955 (4107119) 4107119..4107769 - 651 WP_001037963.1 HNH endonuclease -
QDX04_RS19960 (4107906) 4107906..4108049 + 144 Protein_3906 HNH endonuclease -
QDX04_RS19965 (4108148) 4108148..4108333 + 186 WP_000066585.1 hypothetical protein -
QDX04_RS19970 (4108371) 4108371..4109318 - 948 WP_000342497.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QDX04_RS19975 (4109311) 4109311..4109706 - 396 WP_000152739.1 DUF6088 family protein Antitoxin
QDX04_RS19980 (4109776) 4109776..4110609 - 834 WP_001192741.1 DUF4942 domain-containing protein -
QDX04_RS19985 (4110915) 4110915..4112471 + 1557 WP_000202821.1 type I restriction-modification system subunit M -
QDX04_RS19990 (4112468) 4112468..4113730 + 1263 WP_001293045.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4102166..4113730 11564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35588.79 Da        Isoelectric Point: 4.9737

>T278124 WP_000342497.1 NZ_CP122868:c4109318-4108371 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14605.90 Da        Isoelectric Point: 11.6915

>AT278124 WP_000152739.1 NZ_CP122868:c4109706-4109311 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5BAQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A228Z6F8

References