Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3608341..3609030 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag QDX04_RS17460 Protein ID WP_001460496.1
Coordinates 3608341..3608679 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag QDX04_RS17465 Protein ID WP_001460495.1
Coordinates 3608704..3609030 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS17440 (3603431) 3603431..3605629 + 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
QDX04_RS17445 (3605639) 3605639..3606595 + 957 WP_000121356.1 molybdenum cofactor insertion chaperone PaoD -
QDX04_RS17450 (3606646) 3606646..3606984 + 339 Protein_3415 LysR substrate-binding domain-containing protein -
QDX04_RS17455 (3607343) 3607343..3608119 - 777 WP_230282996.1 hypothetical protein -
QDX04_RS17460 (3608341) 3608341..3608679 - 339 WP_001460496.1 TA system toxin CbtA family protein Toxin
QDX04_RS17465 (3608704) 3608704..3609030 - 327 WP_001460495.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDX04_RS17470 (3609073) 3609073..3609552 - 480 WP_097447683.1 DNA repair protein RadC -
QDX04_RS17475 (3609565) 3609565..3610029 - 465 WP_001460493.1 antirestriction protein -
QDX04_RS17480 (3610090) 3610090..3610908 - 819 WP_097447684.1 DUF932 domain-containing protein -
QDX04_RS17485 (3611371) 3611371..3611994 + 624 WP_001461983.1 inovirus Gp2 family protein -
QDX04_RS17490 (3612113) 3612113..3612328 + 216 WP_001461982.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3580811..3623394 42583
- inside Genomic island - - 3600760..3621324 20564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12771.67 Da        Isoelectric Point: 8.5253

>T278122 WP_001460496.1 NZ_CP122868:c3608679-3608341 [Escherichia coli]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQSHHPSAR

Download         Length: 339 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12552.27 Da        Isoelectric Point: 6.3682

>AT278122 WP_001460495.1 NZ_CP122868:c3609030-3608704 [Escherichia coli]
MEKHDTPEWGLRCDVMPRFSARLVQKNNRLHYLADRAGITGAFKEEECHQLNSAFPHFIEQMELMLLSGELNPRHAHRVT
LYHDELTCEADTLGSCGYVYMAIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References