278121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3419757..3420375 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX04_RS16570 Protein ID WP_001291435.1
Coordinates 3420157..3420375 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX04_RS16565 Protein ID WP_000344800.1
Coordinates 3419757..3420131 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS16555 (3414846) 3414846..3416039 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX04_RS16560 (3416062) 3416062..3419211 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX04_RS16565 (3419757) 3419757..3420131 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX04_RS16570 (3420157) 3420157..3420375 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX04_RS16575 (3420546) 3420546..3421097 + 552 WP_000102556.1 maltose O-acetyltransferase -
QDX04_RS16580 (3421213) 3421213..3421683 + 471 WP_000136192.1 YlaC family protein -
QDX04_RS16585 (3421847) 3421847..3423397 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX04_RS16590 (3423439) 3423439..3423792 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX04_RS16600 (3424171) 3424171..3424482 + 312 WP_000409911.1 MGMT family protein -
QDX04_RS16605 (3424513) 3424513..3425085 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278121 WP_001291435.1 NZ_CP122868:3420157-3420375 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278121 WP_000344800.1 NZ_CP122868:3419757-3420131 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References