278113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1326883..1327508 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDX04_RS06460 Protein ID WP_000911330.1
Coordinates 1327110..1327508 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDX04_RS06455 Protein ID WP_000450524.1
Coordinates 1326883..1327110 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS06430 (1322686) 1322686..1323156 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDX04_RS06435 (1323156) 1323156..1323728 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDX04_RS06440 (1323874) 1323874..1324752 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDX04_RS06445 (1324769) 1324769..1325803 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QDX04_RS06450 (1326016) 1326016..1326729 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDX04_RS06455 (1326883) 1326883..1327110 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDX04_RS06460 (1327110) 1327110..1327508 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDX04_RS06465 (1327655) 1327655..1328518 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QDX04_RS06470 (1328533) 1328533..1330548 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QDX04_RS06475 (1330622) 1330622..1331320 + 699 WP_000679823.1 esterase -
QDX04_RS06480 (1331430) 1331430..1331630 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278113 WP_000911330.1 NZ_CP122868:1327110-1327508 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278113 WP_000450524.1 NZ_CP122868:1326883-1327110 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References