Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 886238..886892 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QDX04_RS04375 Protein ID WP_000244772.1
Coordinates 886485..886892 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDX04_RS04370 Protein ID WP_000354046.1
Coordinates 886238..886504 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS04345 (881407) 881407..882150 + 744 WP_000951961.1 SDR family oxidoreductase -
QDX04_RS04350 (882207) 882207..883640 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
QDX04_RS04355 (883685) 883685..883996 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QDX04_RS04360 (884160) 884160..884819 + 660 WP_000250274.1 hemolysin III family protein -
QDX04_RS04365 (885015) 885015..885995 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
QDX04_RS04370 (886238) 886238..886504 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDX04_RS04375 (886485) 886485..886892 + 408 WP_000244772.1 protein YgfX Toxin
QDX04_RS04380 (886932) 886932..887453 - 522 WP_001055874.1 flavodoxin FldB -
QDX04_RS04385 (887565) 887565..888461 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDX04_RS04390 (888486) 888486..889196 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDX04_RS04395 (889202) 889202..890935 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T278111 WP_000244772.1 NZ_CP122868:886485-886892 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278111 WP_000354046.1 NZ_CP122868:886238-886504 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References